TRPC6-PAM-C20

TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca2+ concentrations ([Ca2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals[1].

Product Specifications

CAS Number

[667427-75-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/trpc6-pam-c20.html

Purity

99.78

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C1C(C2=NC(C)(C)CC3=C2C=C(OC)C(OC)=C3)=CC4=CC=CC=C4O1

Molecular Formula

C22H21NO4

Molecular Weight

363.41

Precautions

H302, H315, H319

References & Citations

[1]S Häfner, et al. Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels. Cell Calcium. 2019 Mar;78:26-34.