Naphthyridine carbamate dimer

Naphthyridine caebamate dimer (NCD) is a DNA molecular glue that induces designed structural changes in target functional DNA to modulate function[1].

Product Specifications

CAS Number

[864627-58-7]

Product Name Alternative

NCD

UNSPSC

12352005

Target

Molecular Glues

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Others; Cancer

Assay Protocol

https://www.medchemexpress.com/naphthyridine-carbamate-dimer.html

Purity

99.68

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NC1=NC2=C(C=C1)C=CC(C)=N2)OCCCNCCCOC(NC3=NC4=C(C=C3)C=CC(C)=N4)=O

Molecular Formula

C26H29N7O4

Molecular Weight

503.55

References & Citations

[1]Yamada T, et, al. NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA. Nucleic Acids Res. 2022 Sep 23;50 (17) :9621-9631. |[2]Simeth NA, et, al. Rational design of a photoswitchable DNA glue enabling high regulatory function and supramolecular chirality transfer. Chem Sci. 2021 May 27;12 (26) :9207-9220.