PROTAC SMARCA2 degrader-6
PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 90 after 24 h of treatment[1].
Product Specifications
CAS Number
[2568523-72-6]
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-6.html
Smiles
O=C([C@H]1N(C[C@H](O)C1)C([C@@H](NC([C@H]2C[C@]3(C[C@H](CN4CCC(CC4)C5=CN=C(N6C7CN(CC6CC7)C8=C(N)N=NC(C9=CC=CC=C9O)=C8)N=C5)C3)C2)=O)C(C)(C)C)=O)NCC%10=CC=C(C%11=C(C)N=CS%11)C=C%10
Molecular Formula
C56H70N12O5S
Molecular Weight
1023.30
References & Citations
[1]Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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