Ro 14-9578
Ro 14-9578 is a tricyclic quinolone analog with antibacterial activity. Ro 14-9578 inhibits DNA biosynthesis (IC50=117 μM) and DNA supercoiling (IC50=66.8 μM) in Escherichia coli. Furthermore, Ro 14-9578 exhibits inhibitory effects against various Gram-negative bacteria and Staphylococcus aureus[1].
Product Specifications
CAS Number
100891-41-6
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ro-14-9578.html
Smiles
O=C(C1=CN2C(C3=C(CC2C)C=C4OCOC4=C3)=CC1=O)O
Molecular Formula
C16H13NO5
Molecular Weight
299.28
References & Citations
[1]Georgopapadakou N H, et al. Monocyclic and tricyclic analogs of quinolones: mechanism of action[J]. Antimicrobial agents and chemotherapy, 1987, 31 (4) : 614-616.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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