PTP1B-IN-1

PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of PTP1B with an IC50 value of 1.6 mM. It is often used as the mother core for derivatives of analogues[1][2].

Product Specifications

CAS Number

[612530-44-6]

Product Name Alternative

PTP1B inhibitor

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319

Target

NF-κB; Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/PTP1B-IN-1.html

Purity

99.65

Solubility

DMSO : ≥ 38 mg/mL

Smiles

O=S(N1C2=CC=CC=C2)(NC(C1)=O)=O

Molecular Formula

C8H8N2O3S

Molecular Weight

212.23

Precautions

H302, H312, H315, H319

References & Citations

[1]Black E, et al. Structure-based design of protein tyrosine phosphatase-1B inhibitors. Bioorg Med Chem Lett. 2005 May 16;15 (10) :2503-7.|[2]Vintonyak VV, et al. Using small molecules to target protein phosphatases. Bioorg Med Chem. 2011 Apr 1;19 (7) :2145-55.|[3]Jiao B, et al., Protein tyrosine phosphatase 1B contributes to neuropathic pain by aggravating NF-κB and glial cells activation-mediated neuroinflammation via promoting endoplasmic reticulum stress. CNS Neurosci Ther. 2024 Feb;30 (2) :e14609.