PTP1B-IN-1
PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of PTP1B with an IC50 value of 1.6 mM. It is often used as the mother core for derivatives of analogues[1][2].
Product Specifications
CAS Number
612530-44-6
Product Name Alternative
PTP1B inhibitor
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319
Target
NF-κB; Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/PTP1B-IN-1.html
Purity
99.65
Solubility
DMSO : ≥ 38 mg/mL
Smiles
O=S(N1C2=CC=CC=C2)(NC(C1)=O)=O
Molecular Formula
C8H8N2O3S
Molecular Weight
212.23
Precautions
H302, H312, H315, H319
References & Citations
[1]Black E, et al. Structure-based design of protein tyrosine phosphatase-1B inhibitors. Bioorg Med Chem Lett. 2005 May 16;15 (10) :2503-7.|[2]Vintonyak VV, et al. Using small molecules to target protein phosphatases. Bioorg Med Chem. 2011 Apr 1;19 (7) :2145-55.|[3]Jiao B, et al., Protein tyrosine phosphatase 1B contributes to neuropathic pain by aggravating NF-κB and glial cells activation-mediated neuroinflammation via promoting endoplasmic reticulum stress. CNS Neurosci Ther. 2024 Feb;30 (2) :e14609.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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