ATN-224
ATN-224 is an orally active Cu2+/Zn2+-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5 nM.
Product Specifications
CAS Number
649749-10-0
Product Name Alternative
Bis (choline) tetrathiomolybdate
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
SOD
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ATN-224.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OCC[N+](C)(C)C.OCC[N+](C)(C)C.[S-][Mo]([S-])(=S)=S
Molecular Formula
C10H28MoN2O2S4
Molecular Weight
432.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Juarez JC, et al. Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12 (16) :4974-82.|[2]Lin J, et al. A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-na?ve prostate cancer. Urol Oncol. 2013 Jul;31 (5) :581-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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