ATN-224

ATN-224 is an orally active Cu2+/Zn2+-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5 nM.

Product Specifications

CAS Number

[649749-10-0]

Product Name Alternative

Bis (choline) tetrathiomolybdate

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

SOD

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ATN-224.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OCC[N+](C)(C)C.OCC[N+](C)(C)C.[S-][Mo]([S-])(=S)=S

Molecular Formula

C10H28MoN2O2S4

Molecular Weight

432.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Juarez JC, et al. Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12 (16) :4974-82.|[2]Lin J, et al. A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-na?ve prostate cancer. Urol Oncol. 2013 Jul;31 (5) :581-8.