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GSK-9772

GSK-9772 is a Liver X Receptor (LXR) modulator of the N-phenyl tertiary amine class (NPTAs) with high affinity for LXR β ligand (IC50=30 nM) . GSK-9772 has anti-inflammatory activity by binding to LXR, specifically by interacting with the region associated with the transcriptional repression function of the receptor, thereby inhibiting the expression of pro-inflammatory genes. GSK-9772 can be used in the study of inflammatory and neurodegenerative diseases[1].

Product Specifications

CAS Number

928035-84-1

UNSPSC

12352005

Target

LXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gsk-9772.html

Smiles

OC1=C(Cl)C=C(CN(CCCC)C2=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C2)C=C1Cl

Molecular Formula

C20H19Cl2F6NO2

Molecular Weight

490.27

References & Citations

[1]EY Chao, et al. Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. Journal of medicinal chemistry 51.18 (2008) : 5758-5765.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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