MG-T-19

MG-T-19 is an effective TIM-3 inhibitor that can suppress the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9. MG-T-19 can increase the production of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in peripheral blood mononuclear cells (PBMCs) from healthy donors, and enhance the ability of PBMCs to inhibit the proliferation of Kasumi-1 cells (an acute myelogenous leukemia cell line) [1].

Product Specifications

CAS Number

[328540-44-9]

UNSPSC

12352101

Target

IFNAR; Tim3; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mg-t-19.html

Concentration

10mM

Purity

98.34

Solubility

DMSO : 14.29 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=C(NC(C2=NN3C(N=C(C4=CC(Br)=CS4)C=C3C(F)(F)F)=C2Br)=O)C=C(Cl)C=C1

Molecular Formula

C18H8Br2ClF3N4O2S

Molecular Weight

596.60

References & Citations

[1]Abdel-Rahman S A, et al. Small molecules from antibody pharmacophores (SMAbPs) as a hit identification workflow for immune checkpoints[J]. Science Advances, 2024, 10 (42) : eadq5540.