(R) - (-) -Rolipram
(R) - (-) -Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
Product Specifications
CAS Number
[85416-75-7]
Product Name Alternative
(R) -Rolipram; (-) -Rolipram
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_R_-_-_-Rolipram.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC[C@@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C1
Molecular Formula
C16H21NO3
Molecular Weight
275.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45 (4) :944.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4
Available Sizes
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