(R)-(-)-Rolipram
Product Specifications
UNSPSC Description
(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_R_-_-_-Rolipram.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC[C@@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C1
Molecular Weight
275.348
References & Citations
[1]Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):944.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16900A/R-minus-Rolipram-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16900A/R-minus-Rolipram-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
85416-75-7
Available Sizes
Curated Selection
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