(R)-(-)-Rolipram

Product Specifications

UNSPSC Description

(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

Target Antigen

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_R_-_-_-Rolipram.html

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC[C@@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C1

Molecular Weight

275.348

References & Citations

[1]Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):944.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-16900A/R-minus-Rolipram-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-16900A/R-minus-Rolipram-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

85416-75-7

Available Sizes

Curated Selection

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