Centmitor-1
Product Specifications
UNSPSC Description
Centmitor-1 (Cent-1) is a mitotic arrest inducer. Centmitor-1 modulates microtubule plus-ends and reduced microtubule dynamics. In cells, Centmitor-1 causes mitotic arrest characterized by chromosome alignment defects, multipolar spindles, centrosome fragmentation, and activated spindle assembly checkpoint[1].
Target Antigen
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/centmitor-1.html
Smiles
O=C1C2=C(N(CC(N/N=C/C3=CC=C(C(Br)=C3)O)=O)C4=C1C=CC=C4)C=CC=C2
Molecular Weight
450.28
References & Citations
[1]Jenni H E Mäki-Jouppila, et al. Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na. Mol Cancer Ther. 2014 May;13(5):1054-66.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124519/Centmitor-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124519/
Clinical Information
No Development Reported
CAS Number
331749-88-3
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