UP12

UP12 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC50 of 1.24 μM[1].

Product Specifications

CAS Number

[443353-87-5]

UNSPSC

12352005

Target

P97

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/up12.html

Purity

97.69

Smiles

O=C(C1=CC=CC=C1)NN2C(SCC(C3=CC=C(C=C3)Cl)=O)=NC4=C(C2=O)C=CC=C4

Molecular Formula

C23H16ClN3O3S

Molecular Weight

449.91

References & Citations

[1]Phan JM, et al., VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models. J Clin Invest. 2024 May 23;134 (14) :e169039.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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