UP12
UP12 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC50 of 1.24 μM[1].
Product Specifications
CAS Number
[443353-87-5]
UNSPSC
12352005
Target
P97
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/up12.html
Purity
97.69
Smiles
O=C(C1=CC=CC=C1)NN2C(SCC(C3=CC=C(C=C3)Cl)=O)=NC4=C(C2=O)C=CC=C4
Molecular Formula
C23H16ClN3O3S
Molecular Weight
449.91
References & Citations
[1]Phan JM, et al., VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models. J Clin Invest. 2024 May 23;134 (14) :e169039.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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