MRS4833
MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC50 of 5.92 nM for hP2Y14R and an IC50 of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model[1].
Product Specifications
CAS Number
[2801627-78-9]
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mrs4833.html
Smiles
O[C@@]1(C2=CC=C(C3=CC(C(O)=O)=CC4=C3C=CC(C5=CC=C(C=C5)C(F)(F)F)=C4)C=C2)[C@]6([H])C[C@@]1([H])CNC6
Molecular Formula
C30H24F3NO3
Molecular Weight
503.51
References & Citations
[1]Wen Z, et al. Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y14 Receptor Antagonists[J]. Journal of Medicinal Chemistry, 2023, 66 (13) : 9076-9094.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y14 Receptor
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