MRS4833
Product Specifications
UNSPSC Description
MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC50 of 5.92 nM for hP2Y14R and an IC50 of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model[1].
Target Antigen
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mrs4833.html
Smiles
O[C@@]1(C2=CC=C(C3=CC(C(O)=O)=CC4=C3C=CC(C5=CC=C(C=C5)C(F)(F)F)=C4)C=C2)[C@]6([H])C[C@@]1([H])CNC6
Molecular Weight
503.51
References & Citations
[1]Wen Z, et al. Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y14 Receptor Antagonists[J]. Journal of Medicinal Chemistry, 2023, 66(13): 9076-9094.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-167855/MRS4833-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-167855/
Clinical Information
No Development Reported
CAS Number
2801627-78-9
Curated Selection
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