Isocytosine

Isocytosine is a non-natural nucleobase and an isomer of cytosine. It is used in combination with Isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA and used as a nucleobase of hachimoji RNA[1][2].

Product Specifications

CAS Number

[108-53-2]

UNSPSC

12352005

Hazard Statement

H302, H319

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Isocytosine.html

Concentration

10mM

Purity

99.71

Solubility

DMSO : 31.82 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N=C(N)NC=C1

Molecular Formula

C4H5N3O

Molecular Weight

111.10

Precautions

H302, H319

References & Citations

[1]"Isocytosine". Molecule of the Week. American Chemical Society. Retrieved November 1, 2012.|[2]Hoshika S, et al. Hachimoji DNA and RNA: A genetic system with eight building blocks. Science. 2019 Feb 22;363 (6429) :884-887.