WRN inhibitor 11
WRN inhibitor 11 (Example 17) is an orally active inhibitor of WRN helicase, with the IC50 of 63 nM[1].
Product Specifications
CAS Number
3058317-61-3
UNSPSC
12352101
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wrn-inhibitor-11.html
Smiles
CCC1=C(C(N2N=C(N=C2N1CC(NC3=CC(Cl)=C(C=C3C)C(F)(F)F)=O)C4=CCOCC4)=O)N5C6CN(C(C7=NC=NC(C)=C7O)=O)CC5CC6
Molecular Formula
C34H35ClF3N9O5
Molecular Weight
742.15
References & Citations
[1]Shanghai Jemincare Pharmaceutical CO., LTD. Heterocyclic compound serving as wrn helicase inhibitor, and preparation method for and use of heterocyclic compound. World Intellectual Property Organization, WO2024199109 A1 2024-03-10
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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