(D-Arg8) -Inotocin
(D-Arg8) -Inotocin is a potent, selective and competitive antagonist of vasopressin receptor (V1aR), with a Ki of 1.3 nM. (D-Arg8) -Inotocin shows more than 3000-fold selectivity for the human V1aR over the other three subtypes, OTR, V1bR and V2R[1].
Product Specifications
CAS Number
745816-74-4
UNSPSC
12352209
Target
Vasopressin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/d-arg8-inotocin.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1NC([C@@H](NC([C@](NC([C@](NC([C@@H](NC([C@H](CSSC1)N)=O)CC(C)C)=O)([H])[C@@H](C)CC)=O)([H])[C@H](O)C)=O)CC(N)=O)=O)N2[C@@H](CCC2)C(N[C@H](CCCNC(N)=N)C(NCC(N)=O)=O)=O
Molecular Formula
C39H68N14O11S2
Molecular Weight
973.17
References & Citations
[1]Giglio MGD, et, al. Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. Sci Rep. 2017 Feb 1;7:41002.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
V1a Receptor
Frequently Asked Questions
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