Human Hyaluronidase PH-20 / SPAM1 Protein, His Tag (active enzyme)
Hyaluronidase PH-20 is also known as Sperm adhesion molecule 1 (SPAM1) and Sperm surface protein PH-20, which belongs to the glycosyl hydrolase 56 family, SPAM1 / PH-20 is expressed in testis. SPAM-1 / PH20 random hydrolysis of (1->4) -linkages between N – acetyl – beta – D – glucosamine and D-glucuronate residues in hyaluronate. SPAM-1 / PH20 involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. SPAM1 aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.
Product Specifications
Background
Specifications
Accession Number
P38567-1
Expression Region
Leu 36 - Tyr 482
Host
HEK293
Target
Hyaluronidase PH-20
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human
Stability
Endotoxin
1.0 EU per μg
Purity
95%
Format
Powder
Buffer
50 mM Tris, 100 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
53.0 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
25ug*1
Host or Source
HEK293
Species
Human
Protein ID
P38567-1
Preservative
Trehalose
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