Acetophenazine

Acetophenazine, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine primarily blocks dopamine D2 receptors in the brain. Acetophenazine can be used for researching psychotic disorders such as schizophrenia and anxious depression[1][2].

Product Specifications

CAS Number

[2751-68-0]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/acetophenazine.html

Purity

98.05

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C1=CC=C(SC2=C3C=CC=C2)C(N3CCCN4CCN(CC4)CCO)=C1)=O

Molecular Formula

C23H29N3O2S

Molecular Weight

411.56

Precautions

H302, H312, H332

References & Citations

[1]Azam Bazrafshan, et al. Acetophenazine versus chlorpromazine for schizophrenia. Cochrane Database of Systematic Reviews. 2015, Issue 4.|[2]Hollister LE, et al. Acetophenazine and diazepam in anxious depressions. Arch Gen Psychiatry. 1971 Mar;24 (3) :273-8.|[3]KNIGHT WR, HOLTZ JR, SPROGIS GR. ACETOPHENAZINE AND FIGHTING BEHAVIOR IN MICE. Science. 1963 Aug 30;141 (3583) :830-1.