Corylin

Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways[1][2][3].

Product Specifications

CAS Number

[53947-92-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; STAT

Type

Natural Products

Related Pathways

Anti-infection; JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Corylin.html

Purity

99.97

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2)=COC4=CC(O)=CC=C14

Molecular Formula

C20H16O4

Molecular Weight

320.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee SW, et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 2012 Jun;78 (9) :903-6.|[2]Chen CC, et al. Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation. Pharmacol Res. 2021 Feb;164:105291.|[3]Chen CY, et al. Corylin Suppresses Hepatocellular Carcinoma Progression via the Inhibition of Epithelial-Mesenchymal Transition, Mediated by Long Noncoding RNA GAS5. Int J Mol Sci. 2018 Jan 27;19 (2) :380.