Cimiside E
Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways[1][2].
Product Specifications
CAS Number
154822-57-8
Product Name Alternative
25-Anhydrocimigenol xyloside
UNSPSC
12352005
Target
Caspase
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cimiside-e.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@@]3([H])[C@@]4(CC[C@@]1([C@]5([H])[C@@]6(O[C@]([C@@H](O6)C(C)=C)([H])C[C@H]5C)[C@@H]2O)C)[C@@]7([C@@](C(C)([C@H](CC7)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)C)([H])CC3)C4
Molecular Formula
C35H54O8
Molecular Weight
602.80
References & Citations
[1]Guo LY, et al. Cimiside E arrests cell cycle and induces cell apoptosis in gastric cancer cells. Arch Pharm Res. 2009 Oct;32 (10) :1385-92. |[2]Jamróz MK, et al. One new and six known triterpene xylosides from Cimicifuga racemosa: FT-IR, Raman and NMR studies and DFT calculations. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Jul;93:10-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3
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