Cimiside E

Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways[1][2].

Product Specifications

CAS Number

[154822-57-8]

Product Name Alternative

25-Anhydrocimigenol xyloside

UNSPSC

12352005

Target

Caspase

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cimiside-e.html

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@@]3([H])[C@@]4(CC[C@@]1([C@]5([H])[C@@]6(O[C@]([C@@H](O6)C(C)=C)([H])C[C@H]5C)[C@@H]2O)C)[C@@]7([C@@](C(C)([C@H](CC7)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)C)([H])CC3)C4

Molecular Formula

C35H54O8

Molecular Weight

602.80

References & Citations

[1]Guo LY, et al. Cimiside E arrests cell cycle and induces cell apoptosis in gastric cancer cells. Arch Pharm Res. 2009 Oct;32 (10) :1385-92. |[2]Jamróz MK, et al. One new and six known triterpene xylosides from Cimicifuga racemosa: FT-IR, Raman and NMR studies and DFT calculations. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Jul;93:10-8.