Nek2/Hec1-IN-1

N-[4- (2,4-Dimethylphenyl) -2-thiazolyl]-4-pyridinecarboxamide is a derivative of INH1 with anticancer activity. It is cytotoxic to MDA-MB-231, MDA-MB-488, HeLa, and K562 cells (IC50s=1.1, 3.4, 1.6, and 1.2 μM, respectively) .

Product Specifications

CAS Number

[560103-80-2]

Product Name Alternative

Nec2/Hec1 inhibitor

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nek2-hec1-in-1.html

Smiles

O=C(C1=CC=NC=C1)NC2=NC(C3=CC=C(C)C=C3C)=CS2

Molecular Formula

C17H15N3OS

Molecular Weight

309.39

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Qiu, et al. Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J. Med. Chem. 52 (6), 1757-1767 (2009) .

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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