Catestatin
Product Specifications
UNSPSC Description
Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide. Catestatin is an endogenous peptide that regulates cardiac function and blood pressure[1]. Catestatin is a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release[2].
Target Antigen
nAChR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/catestatin.html
Purity
98.28
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC2=CC=C(C=C2)O)C(NCC(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCNC(N)=N)C(NCC(N4[C@@H](CCC4)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N
Molecular Weight
2425.82
References & Citations
[1]Nitish R Mahapatra. Catestatin Is a Novel Endogenous Peptide That Regulates Cardiac Function and Blood Pressure. Cardiovasc Res. 2008 Dec 1;80(3):330-8.|[2]Sebastian Kraszewski, et al. A Molecular Dynamics Study of Catestatin Docked on Nicotinic Acetylcholine Receptors to Identify Amino Acids Potentially Involved in the Binding of Chromogranin A Fragments. Phys Chem Chem Phys. 2015 Jul 14;17(26):17454-60.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1271/Catestatin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1271/Catestatin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
142211-96-9
Available Sizes
Curated Selection
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