Catestatin

Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide. Catestatin is an endogenous peptide that regulates cardiac function and blood pressure[1]. Catestatin is a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release[2].

Product Specifications

CAS Number

[142211-96-9]

Product Name Alternative

Catestatin (cattle)

UNSPSC

12352209

Target

NAChR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/catestatin.html

Purity

98.17

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC2=CC=C(C=C2)O)C(NCC(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCNC(N)=N)C(NCC(N4[C@@H](CCC4)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N

Molecular Formula

C107H173N37O26S

Molecular Weight

2425.82

References & Citations

[1]Nitish R Mahapatra. Catestatin Is a Novel Endogenous Peptide That Regulates Cardiac Function and Blood Pressure. Cardiovasc Res. 2008 Dec 1;80 (3) :330-8.|[2]Sebastian Kraszewski, et al. A Molecular Dynamics Study of Catestatin Docked on Nicotinic Acetylcholine Receptors to Identify Amino Acids Potentially Involved in the Binding of Chromogranin A Fragments. Phys Chem Chem Phys. 2015 Jul 14;17 (26) :17454-60.