NCA029
NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with an EC50 of 0.15 μM. NCA029 acts on HsClpP to activate an ATF3-dependent integrative stress response, leading to colon cancer cell death[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; ClpP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nca029.html
Purity
98.24
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=CC=CC(CN2CCC=C(C2)C(NCC3=CC=C(C=C3)C(F)(F)F)=O)=C1
Molecular Formula
C22H20F3N3O
Molecular Weight
399.41
References & Citations
[1]Jiangnan Zhang, et al. Discovery of a Novel Series of Homo sapiens Caseinolytic Protease P Agonists for Colorectal Adenocarcinoma Treatment via ATF3-Dependent Integrated Stress Response. J Med Chem. 2024 Feb 22;67 (4) :2812-2836.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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