HSV-1-IN-1
HSV-1-IN-1 (compound 1b) is a drug candidate for herpes simplex virus HSV-1 (IC50=0.5 nM) and HSV-2 (IC50=16 nM) infection. HSV-1-IN-1 inhibits the helicase-primase complex to prevent viral replication, thereby inhibiting HSV infection[1].
Product Specifications
UNSPSC
12352005
Target
HSV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hsv-1-in-1.html
Solubility
10 mM in DMSO
Smiles
CC1=C(SC(N(C([C@@H]2CC3=C(C2)C=C(C=C3)C4=CC(F)=CC=C4F)=O)C)=N1)S(N)(=O)=O
Molecular Formula
C21H19F2N3O3S2
Molecular Weight
463.52
References & Citations
[1]Gege C, et al. Replacement of sulfonamide by sulfoximine within a helicase-primase inhibitor with restricted flexibility[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129761.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSV-1; HSV-2
Frequently Asked Questions
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