Encorafenib
Product Specifications
UNSPSC Description
Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM).
Target Antigen
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LGX818.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(OC)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C3=CC(Cl)=CC(NS(=O)(C)=O)=C3F)=N1
Molecular Weight
540.01
References & Citations
[1]Compounds and compositions as protein kinase inhibitors
. Patent WO 2011025927 A1|[2]Li Z, et al. Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells. Cancer Lett. 2016 Jan 28;370(2):332-44.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15605/Encorafenib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15605/Encorafenib-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1269440-17-6
Available Sizes
Curated Selection
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