USP5, Human (His)
USP5 protein selectively cleaves branched multiubiquitin polymers, favoring 'Lys-48'-linked polyubiquitin disassembly. It exhibits lower affinity for linear and 'Lys-63'-linked polyubiquitin. USP5 knockdown leads to p53/TP53 accumulation, enhancing p53/TP53 transcriptional activity, as unanchored polyubiquitin competes with ubiquitinated p53/TP53 for proteasomal recognition, unlike MDM2. USP5 Protein, Human (His) is the recombinant human-derived USP5 protein, expressed by E. coli, with N-His labeled tag.
Product Specifications
Product Name Alternative
USP5 Protein, Human (His), Human, E. coli
UNSPSC
12352202
Type
Reference compound
Assay Protocol
https://www.medchemexpress.com/cytokines/usp5-protein-human-his.html
Smiles
Molecular Formula
8078 (Gene_ID) P45974-1 (A2-S858) (Accession)
Molecular Weight
Approximately 97.8 kDa
Shipping Conditions
Dry ice.
Scientific Category
Recombinant Proteins
Frequently Asked Questions
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