VU591 hydrochloride
VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM. VU591 hydrochloride can be used for neurological research with HY-108585A (the equivalent of VU591 hydrochloride).
Product Specifications
CAS Number
1315380-70-1
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu591-hydrochloride.html
Purity
99.0
Solubility
DMSO : 16.67 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=[N+](C1=CC=C2N=C(COCC3=NC4=CC=C([N+]([O-])=O)C=C4N3)NC2=C1)[O-].[H]Cl
Molecular Formula
C16H13ClN6O5
Molecular Weight
404.76
References & Citations
[1]Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79 (1) :42-50.|[2]Masayoshi Okada, et al. Antidepressive effect of an inward rectifier K+ channel blocker peptide, tertiapin-RQ. PLoS One. 2020 Nov 13;15 (11) :e0233815.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
XJB10772-01 0.5 g
3-[ (3,5-Dimethylpiperidin-1-yl) sulfonyl]-4-methoxybenzoic acid
Sign In for Pricing
View Details XJB10772-02 5 g
3-[ (3,5-Dimethylpiperidin-1-yl) sulfonyl]-4-methoxybenzoic acid
Sign In for Pricing
View Details 