Grp94 Inhibitor-1
Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α[1].
Product Specifications
CAS Number
[2234897-35-7]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/grp94-inhibitor-1.html
Purity
98.72
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C2=CC=C(C(C)C)C=C2)=CC=C1N[C@H]3CC[C@H](O)CC3)N
Molecular Formula
C22H28N2O2
Molecular Weight
352.47
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Jiang F, et al. Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis. J Med Chem. 2018 Nov 8;61 (21) :9513-9533.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
Available Sizes
Curated Selection
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