α-Amanitin

α-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.

Product Specifications

CAS Number

[23109-05-9]

Product Name Alternative

α-Amatoxin

UNSPSC

12352203

Hazard Statement

H300, H373

Target

ADC Payload; DNA/RNA Synthesis

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alpha-Amanitin.html

Purity

99.92

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=[S@](C[C@@](NC(CNC([C@@]([C@@H](C)CC)([H])N1)=O)=O)([H])C(N[C@@](C(N(C[C@H](O)C2)[C@]2([H])C3=O)=O)([H])CC(N)=O)=O)C4=C(C[C@](C(NCC1=O)=O)([H])NC([C@](N3)([H])[C@@H](C)[C@@H](O)CO)=O)C5=CC=C(O)C=C5N4

Molecular Formula

C39H54N10O14S

Molecular Weight

918.97

Precautions

H300, H373

References & Citations

[1]Zhao J, et al. Pathological effects of the mushroom toxin alpha-amanitin on BALB/c mice. Peptides. 2006 Dec;27 (12) :3047-3052.|[2]Kume K, et al. α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15. Sci Rep. 2016 May 16;6:25895|[3]Kaya E, et al. Evaluation and comparison of alpha- and beta-amanitin toxicity on MCF-7 cell line. Turk J Med Sci. 2014;44 (5) :728-32|[4]Park MW, et al. RNA Polymerase II Inhibitor, α-Amanitin, Affects Gene Expression for Gap Junctions and Metabolic Capabilities of Cumulus Cells, but Not Oocyte, during in vitro Mouse Oocyte Maturation. Dev Reprod. 2013 Mar;17 (1) :63-72