Lodoxamide

Lodoxamide (U-42585E free acid) is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.

Product Specifications

CAS Number

[53882-12-5]

Product Name Alternative

U-42585E (free acid)

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Lodoxamide.html

Purity

98.07

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC(C(NC1=C(Cl)C(NC(C(O)=O)=O)=CC(C#N)=C1)=O)=O

Molecular Formula

C11H6ClN3O6

Molecular Weight

311.63

Precautions

H302, H312, H332

References & Citations

[1]Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66 (4) :286-94.|[2]Capron M, et al. Inhibitory effects of lodoxamide on eosinophil activation. Int Arch Allergy Immunol. 1998 Jun;116 (2) :140-6.|[3]Barr ML, et al. Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar;115 (3) :631-6; discussion 636-7.|[4]Mann JS, et al. Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study. J Allergy Clin Immunol. 1985 Jul;76 (1) :83-90.