Lansoprazole sulfide
Lansoprazole sulfide is an active metabolite of Lansoprazole by cytochrome P450, possesses anti-cancer activity. Lansoprazole sulfide is an anti-tuberculous agent, with an IC50 of 0.59 µM for M. tb[1].
Product Specifications
CAS Number
103577-40-8
Product Name Alternative
AG-1777
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Drug Metabolite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lansoprazole-sulfide.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)COC1=C(C)C(CSC2=NC3=CC=CC=C3N2)=NC=C1
Molecular Formula
C16H14F3N3OS
Molecular Weight
353.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Jenny Beebe, et al. Therapeutic Activity of the Lansoprazole Metabolite 5-Hydroxy Lansoprazole Sulfide in Triple-Negative Breast Cancer by Inhibiting the Enoyl Reductase of Fatty Acid Synthase. J Med Chem. 2022 Oct 27;65 (20) :13681-13691.|[2]Sipho Mdanda, et al. Lansoprazole-sulfide, pharmacokinetics of this promising anti-tuberculous agent. Biomed Chromatogr. 2017 Dec;31 (12) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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