Lansoprazole sulfide

Lansoprazole sulfide is an active metabolite of Lansoprazole (HY-13662) by cytochrome P450, possesses anti-cancer activity. Lansoprazole sulfide is an anti-tuberculous agent, with an IC50 of 0.59 µM for M. tb[1].

Product Specifications

CAS Number

[103577-40-8]

Product Name Alternative

AG-1777

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Drug Metabolite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lansoprazole-sulfide.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(F)(F)COC1=C(C)C(CSC2=NC3=CC=CC=C3N2)=NC=C1

Molecular Formula

C16H14F3N3OS

Molecular Weight

353.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Jenny Beebe, et al. Therapeutic Activity of the Lansoprazole Metabolite 5-Hydroxy Lansoprazole Sulfide in Triple-Negative Breast Cancer by Inhibiting the Enoyl Reductase of Fatty Acid Synthase. J Med Chem. 2022 Oct 27;65 (20) :13681-13691.|[2]Sipho Mdanda, et al. Lansoprazole-sulfide, pharmacokinetics of this promising anti-tuberculous agent. Biomed Chromatogr. 2017 Dec;31 (12) .