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Recombinant Murine Macrophage-Derived Chemokine/CCL22

Product Specifications

Background

CCL22 is a protein that in mouse is encoded by the CCL22 gene, which locates on the Chr. 8. It is highly expressed in macrophage, monocyte-derived dendritic cell and thymus, additionally, also detected in the tissues of thymus, lymph node and appendix. CCL22 can bind to CCR4, and is a chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells, but not for neutrophils, eosinophils, and resting T-lymphocytes. After secreted from monocyte-derived dendritic cells, the protein can be proteolytic cleaved into three forms: MDC (3-69), MDC (5-69), MDC (7-69) .

Product Name Alternative

STCP-1, MDC (1-69), Macrophage-derived Chemokine

Gene ID

20299

UniProt

O88430

Target

GPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS

Purification

> 97% by SDS-PAGE analyses.

Endotoxin

Less than 1 EU/ugof rMuMDC/CCL22 as determined by LAL method.

Bioactivity

Testing in progress.

Storage Conditions

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculated Molecular Weight

Approximately 7.8 kDa, a single, non-glycosylated polypeptide chain containing 68 amino acids.

Formulation

Lyophilized from a 0.2 μm filtered concentrated solution in 2xPBS, 5% Trehalose, 0.02% Tween-20, pH 7.0.

Host or Source

Escherichia coli

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