CGP71683 hydrochloride

CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a Ki of 1.3 nM, and shows no obvious activity at Y1 receptor (Ki, >4000 nM) and Y2 receptor (Ki, 200 nM) in cell membranes.

Product Specifications

CAS Number

[192322-50-2]

Product Name Alternative

CGP71683A

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Neuropeptide Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/CGP71683_hydrochloride.html

Purity

99.44

Solubility

DMSO : 160 mg/mL (ultrasonic)

Smiles

O=S(C1=C2C=CC=CC2=CC=C1)(NC[C@H]3CC[C@H](CNC4=NC(N)=C5C=CC=CC5=N4)CC3)=O.Cl

Molecular Formula

C26H30ClN5O2S

Molecular Weight

512.07

Precautions

H302, H315, H319

References & Citations

[1]Lecklin A, et al. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br J Pharmacol. 2002 Apr;135 (8) :2029-37.|[2]Costa-e-Sousa RH, et al. Central NPY-Y5 receptors activation plays a major role in fasting-induced pituitary-thyroid axis suppression in adult rat. Regul Pept. 2011 Nov 10;171 (1-3) :43-7.