D-Glucuronic acid

D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity[1][2][3][4][5][6].

Product Specifications

CAS Number

[6556-12-3]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/d-glucuronic-acid.html

Purity

99.79

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O)O)O)O

Molecular Formula

C6H10O7

Molecular Weight

194.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Teng F, et al. Production of d-glucuronic acid from myo-inositol using Escherichia coli whole-cell biocatalyst overexpressing a novel myo-inositol oxygenase from Thermothelomyces thermophile. Enzyme Microb Technol. 2019 Aug;127:70-74.|[2]el-Nezhawy AO, et al. Design, synthesis and antitumor activity of novel D-glucuronic acid derivatives. Med Chem. 2011 Nov;7 (6) :624-38.|[3]Lee J, et al. Effect of D-Glucuronic Acid and N-acetyl-D-Glucosamine Treatment during In Vitro Maturation on Embryonic Development after Parthenogenesis and Somatic Cell Nuclear Transfer in Pigs. Animals (Basel) . 2021 Apr 6;11 (4) :1034.|[4]Müller WE, et al. Purification and characterization of a species-specific aggregation factor in sponges. Exp Cell Res. 1973 Jul;80 (1) :95-104. |[5]Vaith P, et al. On the role of D-glucuronic acid in the aggregation of cells from the marine sponge Geodia cydonium. Dev Comp Immunol. 1979 Spring;3 (2) :259-75.|[6]Lewis SS, et al. Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain Behav Immun. 2013 May;30:24-32.