20-hydroxycholesterol (Highly Pure)

<strong>20-hydroxycholesterol (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2014819_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 1 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> N/A_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> RT_x000D_ <strong>Keywords:</strong> 20-hydroxycholesterol_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Huang Y, Lin Y, Rong M, Liu W, He J, Zhou L. 20(S)-hydroxycholesterol and simvastatin synergistically enhance osteogenic differentiation of marrow stromal cells and bone regeneration by initiation of Raf/MEK/ERK signaling J Mater Sci Mater Med. 2019 Jul 19;30(8):87._x000D_ 2: Faletrov YV, Efimova VS, Horetski MS, Tugaeva KV, Frolova NS, Lin Q, Isaeva LV, Rubtsov MA, Sluchanko NN, Novikova LA, Shkumatov VM. New 20-hydroxycholesterol-like compounds with fluorescent NBD or alkyne labels: Synthesis, in silico interactions with proteins and uptake by yeast cells Chem Phys Lipids. 2020 Mar;227:104850._x000D_ 3: Adhikari R, Chen C, Kim WK. Effect of 20(S)-Hydroxycholesterol on Multilineage Differentiation of Mesenchymal Stem Cells Isolated from Compact Bones in Chicken Genes (Basel). 2020 Nov 17;11(11):1360._x000D_ 4: CONSTANTOPOULOS G, TCHEN TT. Conversion of 20-alpha-hydroxycholesterol to pregnenolone Biochem Biophys Res Commun. 1961 Apr 28;4:460-3._x000D_ 5: Mijares A, Cargill DI, Glasel JA, Lieberman S. Studies on the C-20 epimers of 20-hydroxycholesterol J Org Chem. 1967 Mar;32(3):810-2._x000D_ 6: Kim WK, Meliton V, Amantea CM, Hahn TJ, Parhami F. 20(S)-hydroxycholesterol inhibits PPARgamma expression and adipogenic differentiation of bone marrow stromal cells through a hedgehog-dependent mechanism J Bone Miner Res. 2007 Nov;22(11):1711-9._x000D_ 7: Burstein S, Middleditch BS, Gut M. Mass spectrometric study of the enzymatic conversion of cholesterol to (22R)-22-hydroxycholesterol, (20R,22R)-20,22-dihydroxycholesterol, and pregnenolone, and of (22R)-22-hydroxycholesterol to the lgycol and pregnenolone in bovine adrenocortical preparations. Mode of oxygen incorporation J Biol Chem. 1975 Dec 10;250(23):9028-37._x000D_ 8: HALL PF, KORITZ SB. INHIBITION OF THE BIOSYNTHESIS OF PREGNENOLONE BY 20-ALPHA-HYDROXYCHOLESTEROL Biochim Biophys Acta. 1964 Nov 8;93:441-4._x000D_ 9: SHIMIZU K, DORFMAN RI, GUT M. Isocaproic acid, a metabolite of 20 alpha-hydroxycholesterol J Biol Chem. 1960 Jun;235:PC25._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/19839776">10: Kim WK, Meliton V, Tetradis S, Weinmaster G, Hahn TJ, Carlson M, Nelson SF, Parhami F. Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells J Bone Miner Res. 2010 Apr;25(4):782-95. </a>_x000D_ _x000D_ <strong>Products Related to 20-hydroxycholesterol (Highly Pure) can be found at</strong> <a href="https://moleculardepot.com/product-category/Conjugates/"> Conjugates</a>