Microtubule inhibitor 12
Microtubule inhibitor 12 (Compound 2k) is an inhibitor for microtubule polymerization with an IC50 of 22.23 μM. Microtubule inhibitor 12 arrests the cell cycle of B16-F10 at G2/M phase, induces apoptosis in B16-F10, and inhibits cell migration. Microtubule inhibitor 12 inhibits the proliferation of cancer cells B16-f10, A549, HepG2 and MCF-7, with IC50s of 0.098, 0.135, 0.109, and 0.259 μM, respectively. Microtubule inhibitor 12 exhibits antitumor efficacy in mouse model[1].
Product Specifications
UNSPSC
12352211
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/microtubule-inhibitor-12.html
Smiles
COC1=CC(NC2=NC(C3=C4C=CN(C4=CC=C3)C)=NC=C2)=CC(OC)=C1OC
Molecular Formula
C22H22N4O3
Molecular Weight
390.44
References & Citations
[1]Lin RJ, et al., Design, synthesis and anti-tumor evaluation of novel pyrimidine and quinazoline analogues. Eur J Med Chem. 2025 Jan 15;282:117057.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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