Pyropheophorbide-a

Pyropheophorbide-a (Ppa) is a photosensitizer used in photodynamic therapy (PDT) for tumors. Pyropheophorbide-a exhibits phototoxic effects on tumor cells, such as cervical cancer cells, and also has anti-lipogenesis activity. Pyropheophorbide-a shows potential for research in the fields of cancer and age-related macular degeneration (AMD) . Pyropheophorbide-a derivatives also demonstrate inhibitory activity against tumor cells[1][2][3][4].

Product Specifications

CAS Number

[24533-72-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pyropheophorbide-a.html

Purity

98.0

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

CC1=C2C(N/C1=C\3)=C(CC2=O)C([C@H]4CCC(O)=O)=N/C([C@H]4C)=C\C5=C(C)C(C=C)=C(N5)/C=C6C(C)=C(CC)C3=N/6

Molecular Formula

C33H34N4O3

Molecular Weight

534.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Li W, et al. cRGD Peptide-Conjugated Pyropheophorbide-a Photosensitizers for Tumor Targeting in Photodynamic Therapy. Mol Pharm. 2018 Apr 2;15 (4) :1505-1514.|[2]Liu YH, et al. Anti-adipogenic activities of pheophorbide a and pyropheophorbide a isolated from wild bitter gourd (Momordica charantia L. var. abbreviata Seringe) in vitro. J Sci Food Agric. 2022 Nov;102 (14) :6771-6779.|[3]Bao L L, et al. In vitro and in vivo evaluation of a pyropheophorbide-a derivative as a potential photosensitizer for age-related macular degeneration[J]. Biomedicine & Pharmacotherapy, 2017, 88: 1220-1226.|[4]Chaturvedi P K, et al. Phototoxic effects of pyropheophorbide-a from chlorophyll-a on cervical cancer cells[J]. Journal of Porphyrins and Phthalocyanines, 2014, 18 (03) : 182-187.