L-Phenylalanine-13C9,15N, d8
L-Phenylalanine-13C9,15N, d8 is the deuterium, 13C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S) -2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
Product Specifications
CAS Number
1994331-22-4
Product Name Alternative
(S) -2-Amino-3-phenylpropionic acid-13C9,15N, d8
UNSPSC
12352005
Target
Calcium Channel; Endogenous Metabolite; iGluR; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Solubility
10 mM in DMSO
Smiles
O[13C]([13C@]([2H])([13C]([2H])([13C]1=[13C]([13C]([2H])=[13C]([13C]([2H])=[13C]1[2H])[2H])[2H])[2H])[15NH2])=O
Molecular Formula
13C9H3D8 15NO2
Molecular Weight
183.17
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Available Sizes
Frequently Asked Questions
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