GYKI-47261
GYKI-47261 is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 is also a potent inducer of CYP2E1[1][2].
Product Specifications
CAS Number
220445-20-5
UNSPSC
12352005
Target
Cytochrome P450; iGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gyki-47261.html
Smiles
NC1=CC=C(C2=NN3C(CC4=CC=C(Cl)C=C42)=NC(C)=C3)C=C1
Molecular Formula
C18H15ClN4
Molecular Weight
322.79
References & Citations
[1]Abrahám G, et al. New non competitive AMPA antagonists. Bioorg Med Chem. 2000;8 (8) :2127-2143.|[2]Tamási V, et al. GYKI-47261, a new AMPA [2-amino-3- (3-hydroxymethylisoxazole-4-yl) propionic acid] antagonist, is a CYP2E1 inducer. Drug Metab Dispos. 2003;31 (11) :1310-1314.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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