SG-209

SG-209 is a Nicorandil (HY-B0341) derivative that produces relaxation through potassium channel activation, while this action contributes to the vasodilating action of Nicorandil (HY-B0341) at higher concentrations. SG-209 dilates tracheal smooth muscle and increases tracheal blood flow in anesthetized dogs[1][2].

Product Specifications

CAS Number

[83440-03-3]

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sg-209.html

Smiles

O=C(C1=CC=CN=C1)NCCOC(C)=O

Molecular Formula

C10H12N2O3

Molecular Weight

208.21

References & Citations

[1]Ishibashi T, et al. 2-Nicotinamidoethyl acetate (SG-209) is a potassium channel opener: structure activity relationship among nicorandil derivatives. Naunyn Schmiedebergs Arch Pharmacol. 1991 Aug;344 (2) :235-9. |[2]Yonekura H, et al. Effects of N- (2-hydroxyethyl) nicotinamide nitrate (nicorandil; SG-75) and its derivatives on pancreatic exocrine secretion in the dog. Pancreas. 1990;5 (1) :75-81.