UVI 3003
Product Specifications
UNSPSC Description
UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively.
Target Antigen
Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Autophagy;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/UVI_3003.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCOC1=C(C2=CC(/C=C/C(O)=O)=CC=C2O)C=C3C(C(C)(CCC3(C)C)C)=C1
Molecular Weight
436.58
References & Citations
[1]Zhu J, et al. The unexpected teratogenicity of RXR antagonist UVI3003 via activation of PPARγ in Xenopus tropicalis. Toxicol Appl Pharmacol. 2017 Jan 1;314:91-97.|[2]Hebert SL, et al. Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro. Exp Cell Res. 2017 Dec 1;361(1):101-111.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-107500/UVI-3003-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-107500/UVI-3003-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
847239-17-2
Available Sizes
Curated Selection
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