UVI 3003
UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively.
Product Specifications
CAS Number
847239-17-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/UVI_3003.html
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCOC1=C(C2=CC(/C=C/C(O)=O)=CC=C2O)C=C3C(C(C)(CCC3(C)C)C)=C1
Molecular Formula
C28H36O4
Molecular Weight
436.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhu J, et al. The unexpected teratogenicity of RXR antagonist UVI3003 via activation of PPARγ in Xenopus tropicalis. Toxicol Appl Pharmacol. 2017 Jan 1;314:91-97.|[2]Hebert SL, et al. Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro. Exp Cell Res. 2017 Dec 1;361 (1) :101-111.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
RK11548 96 Tests
Human Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ELISA Kit
Sign In for Pricing
View Details 
MBS6363269-01 0.2 mL
WDR43, CT (WDR43, KIAA0007, WD repeat-containing protein 43) (AP)
Sign In for Pricing
View Details MBS6363269-02 5x 0.2 mL
WDR43, CT (WDR43, KIAA0007, WD repeat-containing protein 43) (AP)
Sign In for Pricing
View Details