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KN-92 (hydrochloride)

KN-92 hydrochloride is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 hydrochloride is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93[1][2].

Product Specifications

CAS Number

1431698-47-3

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CaMK

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/KN-92-hydrochloride.html

Purity

99.99

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(OC)C=C1)(NC2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)=O.[H]Cl

Molecular Formula

C24H26Cl2N2O3S

Molecular Weight

493.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277 (38) :35061-35070.|[2]An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13 (9) :1445-1448.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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