Phelorphan
Phelorphan is a purine MTH1 inhibitor identified through chemical array screening. Although it targets cellular MTH1, its cytotoxicity to cancer cells is weaker than that of other reported inhibitors. The cytotoxicity of MTH1 inhibitors may be attributed to off-target effects, and MTH1 is not essential for cancer cell survival.
Product Specifications
CAS Number
110871-16-4
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/phelorphan.html
Smiles
O=C([C@@H](NC([C@@H](NC(CS)=O)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)O
Molecular Formula
C20H22N2O4S
Molecular Weight
386.46
References & Citations
[1]Synthesis of enkephalinase B inhibitors, and their activity on isolated enkephalin-degrading enzymes
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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