EMD638683
EMD638683 is a highly selective SGK1 inhibitor, with an IC50 value of 3 μM.
Product Specifications
CAS Number
1181770-72-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
SGK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/EMD638683.html
Purity
99.94
Solubility
DMSO : ≥ 50 mg/mL
Smiles
CC1=C(CC)C(C(NNC(C(O)C2=CC(F)=CC(F)=C2)=O)=O)=CC=C1O
Molecular Formula
C18H18F2N2O4
Molecular Weight
364.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Ackermann TF, et al. EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem. 2011;28 (1) :137-46.|[2]Towhid ST, et al. Inhibition of colonic tumor growth by the selective SGK inhibitor EMD638683. Cell Physiol Biochem. 2013;32 (4) :838-48.|[3]Xi X, et al. Serum-glucocorticoid regulated kinase 1 regulates macrophage recruitment and activation contributing to monocrotaline-induced pulmonary arterial hypertension. Cardiovasc Toxicol. 2014 Dec;14 (4) :368-78.|[4]Zhou H, et al. Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure. FASEB J. 2015 Sep;29 (9) :3737-49.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SGK1
Available Sizes
Frequently Asked Questions
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