What is the catalog number for EMD638683?

The catalog number for EMD638683 is HY-15193.

What sizes are available for EMD638683?

EMD638683 is available in the following size(s): 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does EMD638683 come in?

EMD638683 is available in 6 different pack sizes.

Is EMD638683 in stock?

EMD638683 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures EMD638683?

EMD638683 is manufactured by QuantiMol.

What is the estimated delivery time for EMD638683?

Estimated delivery time for EMD638683 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for EMD638683?

The safety data sheet for EMD638683 is available here: http://file.medchemexpress.com/batch_PDF/HY-15193/EMD638683-SDS-MedChemExpress.pdf.

EMD638683

EMD638683 is a highly selective SGK1 inhibitor, with an IC50 value of 3 μM.

Product Specifications

CAS Number

1181770-72-8

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

SGK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/EMD638683.html

Purity

99.94

Solubility

DMSO : ≥ 50 mg/mL

Smiles

CC1=C(CC)C(C(NNC(C(O)C2=CC(F)=CC(F)=C2)=O)=O)=CC=C1O

Molecular Formula

C18H18F2N2O4

Molecular Weight

364.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Ackermann TF, et al. EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem. 2011;28 (1) :137-46.|[2]Towhid ST, et al. Inhibition of colonic tumor growth by the selective SGK inhibitor EMD638683. Cell Physiol Biochem. 2013;32 (4) :838-48.|[3]Xi X, et al. Serum-glucocorticoid regulated kinase 1 regulates macrophage recruitment and activation contributing to monocrotaline-induced pulmonary arterial hypertension. Cardiovasc Toxicol. 2014 Dec;14 (4) :368-78.|[4]Zhou H, et al. Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure. FASEB J. 2015 Sep;29 (9) :3737-49.