EMD638683

EMD638683 is a highly selective SGK1 inhibitor, with an IC50 value of 3 μM.

Product Specifications

CAS Number

[1181770-72-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

SGK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/EMD638683.html

Purity

99.94

Solubility

DMSO : ≥ 50 mg/mL

Smiles

CC1=C(CC)C(C(NNC(C(O)C2=CC(F)=CC(F)=C2)=O)=O)=CC=C1O

Molecular Formula

C18H18F2N2O4

Molecular Weight

364.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Ackermann TF, et al. EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem. 2011;28 (1) :137-46.|[2]Towhid ST, et al. Inhibition of colonic tumor growth by the selective SGK inhibitor EMD638683. Cell Physiol Biochem. 2013;32 (4) :838-48.|[3]Xi X, et al. Serum-glucocorticoid regulated kinase 1 regulates macrophage recruitment and activation contributing to monocrotaline-induced pulmonary arterial hypertension. Cardiovasc Toxicol. 2014 Dec;14 (4) :368-78.|[4]Zhou H, et al. Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure. FASEB J. 2015 Sep;29 (9) :3737-49.